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中年阿爾茲海默癥生物標(biāo)志物變化可預(yù)測老年癡呆發(fā)生
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α2-巨球蛋白樣蛋白1(a2ML1)重組蛋白 α-2-巨球蛋白(α-2M)是一種同源四聚體血清蛋白,由四個(gè)相同的亞基組成,通過二硫鍵形成二聚體。最初,α-2M被描述為一種泛蛋白酶抑制劑,能夠“引誘"蛋白酶切割α-2M上的特定肽序列。這種相互作用誘導(dǎo)α-2M的構(gòu)象變化,從而使其能夠“捕獲"蛋白酶并進(jìn)一步抑制其活性。隨后,α-2M已被證明在炎癥過程中作為載體蛋白和細(xì)胞因子的調(diào)節(jié)因子發(fā)揮作用。血清中的循
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品牌 | 信裕生物 | CAS | 詳見說明書 |
---|---|---|---|
分子式 | 詳見說明書 | 純度 | > 90% |
分子量 | 28.9kDa | 貨號 | XY90279RPHu |
規(guī)格 | 50µg/100µg | 供貨周期 | 一周 |
主要用途 | SDS-PAGE; WB | 應(yīng)用領(lǐng)域 | 生物產(chǎn)業(yè) |
Recombinant Alpha-2-Macroglobulin Like Protein 1 (a2ML1)
α2-巨球蛋白樣蛋白1(a2ML1)重組蛋白
[ PROPERTIES ]
Source: Prokaryotic expression
Host: E.coli
Residues: Gln1119~Thr1348
Tags: N-terminal His Tag
Subcellular Location: Secreted
Purity: > 90%
Traits: Freeze-dried powder
Buffer formulation: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT,0.01% SKL, 5% Trehalose and Proclin300.
Original Concentration: 200µg/mL
Applications: Positive Control; Immunogen; SDS-PAGE; WB.
(May be suitable for use in other assays to be determined by the end user.)
Predicted isoelectric point: 8.9
Predicted Molecular Mass: 28.9kDa
Accurate Molecular Mass: 29kDa as determined by SDS-PAGE reducing conditions.
[ USAGE ]
Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do notvortex.
[ STORAGE AND STABILITY ]
Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8oC for one month.
Aliquot and store at -80oC for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
[SEQUENCE ]
[ IDENTIFICATION ]
[ IMPORTANT NOTE ]
The kit is designed for research use only, we will not be responsible for any issue if the kit was used in clinical diagnostic or any other procedures.
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