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線粒體蛋白酪氨酸磷酸酶1(PTPMT1)重組蛋白 是硫嘌呤類藥物(如硫唑嘌呤、巰嘌呤和硫鳥嘌呤)的代謝中最主要的酶之一,起到的作用是在這類化合物的硫原子上增加一個甲基;這個過程中提供甲基的是S-腺苷甲硫氨酸,后者同時被轉(zhuǎn)化成S-腺苷-L-高半胱氨酸。 TPMT基因的缺陷會讓人體無法將這類藥物滅活,未代謝的藥物因此在體內(nèi)大量累積,從而引起嚴(yán)重甚至致命的骨髓抑制,表現(xiàn)為貧血、血小板減少癥(導(dǎo)致
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品牌 | 信裕生物 | CAS | 詳見說明書 |
---|---|---|---|
分子式 | 詳見說明書 | 純度 | > 95% |
分子量 | 26.9kDa | 貨號 | XY94203RPHu |
規(guī)格 | 50µg/100µg | 供貨周期 | 一周 |
主要用途 | SDS-PAGE; WB | 應(yīng)用領(lǐng)域 | 生物產(chǎn)業(yè) |
Recombinant Protein Tyrosine Phosphatase, Mitochondrial 1 (PTPMT1)
線粒體蛋白酪氨酸磷酸酶1(PTPMT1)重組蛋白
[ PROPERTIES ]
Source:Prokaryotic expression
Host: E.coli
Residues: Leu26~His227
Tags:N-terminal His Tag
Tissue Specificity: Kidney, Bone marrow, Cervix carcinoma, Liver.
Subcellular Location: Cytoplasm
Purity: > 95%
Traits:Freeze-dried powder
Buffer formulation: 100mM NaHCO3, 500mM NaCl, pH8.3, containing1mMEDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300.
Original Concentration:200µg/mL
Applications:Positive Control; Immunogen; SDS-PAGE; WB.
(May be suitable for use in other assays to be determined by the end user.)
Predicted isoelectric point:6.7
Predicted Molecular Mass: 26.9kDa
Accurate Molecular Mass: 27kDa as determined by SDS-PAGE reducingconditions
[ USAGE ]
Reconstitute in 100mM NaHCO3, 500mM NaCl (pH8.3) to a concentrationof0.1-1.0 mg/mL. Do not vortex.
[ STORAGE AND STABILITY ]
Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8oC for one month.
Aliquot and store at -80oC for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
[SEQUENCE ]
[ IDENTIFICATION ]
[ IMPORTANT NOTE ]
The kit is designed for research use only, we will not be responsible for any issue if the kit was used in clinical diagnostic or any other procedures.
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